Top 10 Biggest Upsets of the 2025–26 Season

The largest spreads that flipped — ranked by how heavy a favorite the winner was supposed to beat.

#1
Eastern Michigan def. Cincinnati
Nov 26, 2025 · CIN -22.5 · Dog ML +1800
-22.5 EMU 64, CIN 56

Cincinnati was a 22.5-point home favorite — a spread the market reserves for near-exhibitions. Eastern Michigan was a MAC road visitor with nothing to lose. EMU won 64–56, controlling a game the model rated as 98% for Cincinnati at tipoff.

The books priced Cincinnati's moneyline at -5000. A $5,000 bet to win $100. Eastern Michigan players presumably did not have that position.

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#2
Portland def. Gonzaga
Feb 4, 2026 · GONZ -22.5 · Dog ML +1800
-22.5 POR 87, GONZ 80

Gonzaga took a 22.5-point road spread to the Morrison Center — in the same WCC the Bulldogs have dominated for twenty years. The Pilots won 87–80. What distinguished this loss was context: earlier in November, Gonzaga had gone to Ann Arbor as a 3.5-point road favorite and lost by 40. A program that volatile is capable of losing by 7 to a team they were supposed to beat by 22.

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#3
Delaware def. George Washington
Dec 10, 2025 · GW -21.5 · Dog ML +1500
-21.5 DEL 70, GW 58

George Washington, a 21.5-point home favorite in early December, lost 58–70 to Delaware. The Blue Hens won by 12. A spread that implied a comfortable home win resolved as a double-digit road victory for the CAA visitor.

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#4
Wisconsin def. Michigan
Jan 10, 2026 · MICH -19.5 · Dog ML +1600
-19.5 WIS 91, MICH 88

Michigan was a 19.5-point home Big Ten favorite — an enormous intra-conference number implying a significant talent gap between programs in the same league. Wisconsin won 91–88 in a high-scoring game decided in the final minutes. The Wolverines' market standing at that point vastly overstated where they actually were as a team; this result was an early indicator.

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#5
Georgia Tech def. NC State
Jan 17, 2026 · NCSU -17.5 · Dog ML +1200
-17.5 GT 78, NCSU 74

NC State, a 17.5-point home favorite in ACC conference play, lost 74–78 to Georgia Tech. The Yellow Jackets won outright by 4, covering by 21.5 on a spread that treated the game as a near-foregone conclusion.

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#6
West Georgia def. Troy
Dec 1, 2025 · TROY -17.5 · Dog ML +1100
-17.5 WG 93, TROY 89

Troy dropped a 17.5-point home game to West Georgia 89–93. West Georgia, an ASUN program visiting on the road, scored 93 in a game Troy was expected to win comfortably. They didn't win at all.

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#7
North Alabama def. San Francisco
Dec 3, 2025 · SF -16.5 · Dog ML +1400
-16.5 UNA 65, SF 63

North Alabama won 65–63 on the road against San Francisco, a 16.5-point home favorite. The margin of victory: two points. The moneyline: +1400. The simplest version of what happened — a team expected to lose by 16 won by 2.

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#8
Arkansas–Pine Bluff def. UIC
Dec 3, 2025 · UIC -16.5 · Dog ML +950
-16.5 UAPB 63, UIC 62

Arkansas–Pine Bluff — an HBCU from the SWAC — won at UIC 63–62 as a 16.5-point road underdog. One point separated an upset from a cover in what was supposed to be an uncompetitive game. The +950 ML implied roughly a 10% win probability. They won by one.

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#9
Coastal Carolina def. Winthrop
Dec 6, 2025 · WIN -16.5 · Dog ML +1000
-16.5 CCU 88, WIN 84

Coastal Carolina won 88–84 on the road against Winthrop, a 16.5-point home favorite. CCU scored 88 in a game where the market expected them to lose by a comfortable margin — and won going away.

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#10
Howard def. UNC Wilmington
Dec 20, 2025 · UNCW -15.5 · Dog ML +850
-15.5 HOW 67, UNCW 66

Howard won 67–66 at UNC Wilmington as a 15.5-point road underdog — by a single point. The Seahawks were a 15.5-point home favorite; the game was decided by one basket. The +850 moneyline implied Howard had roughly an 11% chance. They needed every point they scored.

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